Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine tlr9 inhibitor Hydroxychloroquine and alcohol consumption I asked her for plaquenil since it's a non steroid anti inflammatory. She seemed hesitant to prescribe it. She told me that it could make me feel better or much much worse. She said after 3 days of burbur detox I could try 1/2 tablet of plaquenil every other day, but if i start feeling worse to stop immediately. Does anyone else feel worse on Plaquenil? Support Forums Rheumatoid Arthritis New Topic Reply. Made me feel out of it all the time, sort of dizzy and ou of balance. I had to go off it after 6 weeks. They put me on methotrexate and that worked much better. Goodluck, golitho Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine makes me feel worse Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Does anyone else feel worse on Plaquenil? Symptoms of plaquenil toxicityPlaquenil package insertClaritin and plaquenilHydroxychloroquine and methotrexate interactionHydroxychloroquine and weightloss Methylfolate Makes Depression Worse For Me – Now What? Don’t worry – you have a couple of options. If you’re sure this isn’t just your body adjusting to methylfolate the symptoms last beyond the first week of moderate supplementation then it’s time to check to see if you fit the profile of an undermethylator. If that sounds like. Methylfolate Makes Depression WORSE! To Health With That!. Hydroxychloroquine Reviews Everyday Health. Hydroxychloroquine Side-effects, uses, time to work. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Does Hydroxychloroquine make you feel down. if it's anything like me I get 'man flu' you do actually feel much worse trying to fight a cold off with RA, the.