She had been taking hydroxychloroquine as a disease-modifying agent for about 15 years. A transthoracic echocardiogram showed reduced left ventricular function with an ejection fraction of 35% (A, Online Video 1). Hydroxychloroquine mechanism of action in sle Hydroxychloroquine chest x ray Hydroxychloroquine cost uk Hydroxychloroquine diabetes 2019 Genetic predisposition for HCQ‐induced cardiomyopathy was first proposed in a set of twin sisters who both suffered from SLE. 9 Chatre et al. described a case of a 61‐year‐old woman whose diagnosis of α‐galactosidase A deficiency was unmasked by chronic HCQ treatment. 10 Because Fabry disease and other lysosomal storage disorders, such. Soong TR, Barouch LA, Champion HC et al 2007 New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy—a report of 2 cases. Hydroxychloroquine is used in the treatment of various rheumatic conditions including systemic lupus erythematous. Hydroxychloroquine induced myopathy is rare adverse reaction but symptoms are usually recover after discontinuation of the drug. Here we report a case of woman with systemic lupus erythematosus who presented with myopathy after eight months treatment with hydroxychloroquine. Periodic-acid Schiff staining showed glycogen deposition in myocyte cytoplasm. Subsequent coronary angiography revealed normal coronary arteries. Hematoxylin and eosin staining revealed myocyte vacuolization (B). Plaquenil induced cardiomyopathy A Rare but Reversible Cause of Myopathy Hydroxychloroquine., Hydroxychloroquine-induced cardiomyopathy in a patient with. Chloroquine pretreatment degradationOral plaquenil eye examPlaquenil and period changesHydroxychloroquine 200 mg discountsHydroxychloroquine 200 mg tab side effects Drug-induced cardiotoxicity including chemotherapy-induced cardiotoxicity remains an important cause of heart disease and heart failure.1, 2, 3 Cardiomyopathy from cancer chemotherapy is well recognized as a drug-induced complication but the cardiotoxicity from other drugs is not well described.2, 3 Chloroquine CQ and hydroxychloroquine HCQ are 4-aminoquinolines 4 at one time commonly used. Hydroxychloroquine-Induced Cardiomyopathy Case Report, Pathophysiology.. A Rare but Reversible Cause of Myopathy.. Drug-induced myopathies - UpToDate. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. In rare cases, Plaquenil can cause cardiomyopathy, a chronic disease of the heart muscle. If you're taking Plaquenil for an autoimmune condition, your symptoms should begin to improve after a few. Cardiac disorders Cardiomyopathy which may result in cardiac failure and in some cases a fatal outcome see WARNINGS and OVERDOSAGE. PLAQUENIL prolongs the QT interval. Ventricular arrhythmias and torsade de pointes have been reported in patients taking PLAQUENIL see OVERDOSAGE and DRUG INTERACTIONS.