Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine resistance to antimalarail drugs Plaquenil brand name covered by insurance Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Accordingly, inhibitors of autophagy including chloroquine and hydroxychloroquine have been shown to mediate substantial antineoplastic effects in preclinical models, especially when combined with chemo- or radiotherapeutic interventions. TACE,176, 177 in patients with unresectable HCC NCT02013778; 10. Hepatocellular carcinoma HCC is the fifth most common cancer in the world and the third cause of cancer mortality. Surgical resection or liver transplantation is the main therapeutic strategy. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine hcc Autophagy promotes hepatocellular carcinoma cell invasion., Chloroquine and hydroxychloroquine for cancer therapy Chloroquine use in thailandDrug price for hydroxychloroquineHydroxychloroquine sulphate in swedenReceptor tyrosine kinase dengue virus chloroquinePlaquenil for arthritis Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine - Wikipedia. Autophagy inhibition sensitizes hepatocellular carcinoma.. Chloroquine inhibits hepatocellular carcinoma cell growth.. In all four chloroquine-treated HCC cell lines with notably blocked autophagy flux, no significant difference of doxorubicin sensitivity could be found between the Introduction. Hepatocellular carcinoma HCC ranks the fifth most common cancer and is the third leading cause of death from cancer worldwide 1. Although surgery is the optimal treatment for liver cancer, only 10%-30% of patients are able to take the radical resection as most of them are detected at advanced stages when they have lost the opportunity of surgical therapy 2, 3. Chloroquine CQ is a classic drug for the treatment of malarial. Recently, CQ has been widely used as an enhancing agent in cancer therapies and has a synergistic effect with ionizing radiation or chemotherapeutic agents in a cancer-specific manner 4–9.